نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشجو دکترا، گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه آزاد اسلامی واحد بجنورد، بجنورد، خراسان شمالی، ایران
2 استادیار، گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه آزاد اسلامی واحد بجنورد، بجنورد، خراسان شمالی، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background and Aims:
Given the established link between obesity and neurological disorders, this study aimed to compare the effects of interval and continuous training on neurodegenerative factors in obese diabetic male rats.
Materials and Methods:
Twenty male Wistar rats (10 weeks old, 250±50g) were divided into four groups: healthy control, diabetic control, interval training, and continuous training. Diabetes was induced via a high-fat diet and streptozotocin injection. Training was conducted five days per week for eight weeks. Gene expression of GSK-3β and CRMP2 was analyzed using Real Time-PCR, and data were evaluated with one-way ANOVA and Tukey’s post hoc test (p<0.05).
Results:
GSK-3β expression significantly decreased in both training groups compared to the diabetic control (p=0.001 and p=0.003), with no significant difference between training groups (p=0.580).
CRMP2 expression was significantly lower in both training groups compared to the diabetic control (p=0.001 and p=0.005), with interval training showing a greater reduction than continuous training (p=0.043).
Conclusion:
Exercise training, particularly interval training, may serve as both a therapeutic and preventive strategy against the progression of obesity, type 2 diabetes, and neurodegenerative diseases.
کلیدواژهها [English]
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