تأثیر 12 هفته ورزش در آب و مصرف مکمّل امگا3 برمقادیر سرمی BDNF و TNFدر مردان مبتلا به بیماری مولتیپیل اسکلروزیس

نوع مقاله : مقاله پژوهشی

نویسنده

کارشناسی ارشد، گروه تربیت بدنی، دانشگاه پیام‌ نور، مهاباد، ایران

10.22091/arsnes.2024.11223.1015

چکیده

هدف: هدف پژوهش حاضر بررسی تاثیر 12 هفته ورزش در آب و مصرف مکمّل امگا 3 بر مقادیر سرمی BDNF و TNF در مردان مبتلا به بیماری مولتیپیل اسکلروزیس بود.
روش: 40 مرد مبتلا به ام.اس. از بین مردان مراجعه‌کننده به یکی از مراکز معتبر شهرستان مهاباد که دارای پرونده پزشکی بوده و به تشخیص پزشک متخصص مغز و اعصاب وجود بیماری ام.اس. در آنها به اثبات رسیده و تحت درمان بودند، با دامنه سنی 35-40 در قالب یک طرح نیمه‌تجربی با پیش‌آزمون و پس‌آزمون، به صورت تصادفی انتخاب شدند و در چهار گروه 10 نفره تمرین+ مکمّل، تمرین+ دارونما، مکمّل امگا3 و گروه کنترل تقسیم شدند. گروه‌های مداخله، تمرینات ورزشی را به مدت 12 هفته، هفته‌ای 3 جلسه 60 دقیقه‌ای انجام دادند. گروه‌های مکمّل، روزانه دو گرم امگا3 که به صورت 3 کپسول ژلی بود را به میزان سه بار در روز پس از هر وعده غذایی مصرف می‌کردند. تجزیه و تحلیل داده‌ها با استفاده از نرم‌افزار آماری SPSS-22 انجام شد. جهت بررسی طبیعی بودن توزیع داده‌ها از آزمون شاپیرو- ویلک استفاده شد. بعد از حصول اطمینان از طبیعی بودن توزیع داده‌ها، جهت مقایسه میانگین نمرات پیش‌آزمون و پس‌آزمون شاخص‌های گروه‌های تجربی و گروه کنترل، از آزمون تحلیل کوواریانس، و جهت مقایسه تفاوت بین داده‌های چهار گروه از آزمون تعقیبی توکی 3 استفاده شد.
یافته‌ها: تمرینات ورزشی به همراه مصرف امگاه3 باعث افزایش BDNF در گروه‌ها در مقایسه با گروه کنترل شد، ولی این افزایش در گروه تمرین + مکمّل نسبت به دیگر گروه‌ها بیشتر بود (p<0/05). نتایج در گروه‌های مداخله نسبت به گروه کنترل کاهش معنی‌داری TNF-α را نشان داد (p<0/05).
نتیجه‌گیری: مصرف امگا 3 به عنوان یک مکمّل می‌تواند اثر مثبتی بر افزایش مقادیر BDNFو کاهش مقادیر TNF-α در مردان مبتلا به ام.اس. داشته باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effects of 12 Weeks of Aquatic Exercise and Omega-3 Supplementation on Serum BDNF and TNF Levels in Men with Multiple Sclerosis

نویسنده [English]

  • Bakhtiar Hasan
Master's degree, Department of Physical Education, Payam Noor University, Mahabad, Iran.
چکیده [English]

Objective: The aim of the present study was to investigate the effects of 12 weeks of aquatic exercise and omega-3 supplementation on serum levels of BDNF and TNF in men with multiple sclerosis.
Method: A total of 40 men aged 35 to 40 with multiple sclerosis (MS) were randomly selected from a pool of individuals referred to a reputable center in Mahabad. All participants had a documented medical history and had been diagnosed with MS by a neurologist. They were undergoing treatment at the time of selection. This study employed a quasi-experimental design featuring both pre-test and post-test assessments. The participants were divided into four groups of 10: exercise with + supplementation, exercise with + a placebo, omega-3 supplementation, and a control group. The intervention groups engaged in exercise training for 12 weeks, participating in three 60-minute sessions each week. The supplement groups consumed 2 grams of omega-3 in the form of three gel capsules, taken three times a day after each meal. Data analysis was conducted using SPSS version 22 statistical software. The Shapiro-Wilk test was employed to assess the normality of the data distribution. After confirming the normality of the data distribution, an analysis of covariance (ANCOVA) was conducted to compare the mean pre-test and post-test scores of the experimental and control groups. Additionally, Tukey's post-hoc test was employed to analyze the differences among the data from the four groups.
Findings: Exercise training combined with omega-3 supplementation resulted in a significant increase in Brain-Derived Neurotrophic Factor (BDNF) in the intervention groups compared to the control group. Notably, this increase was more pronounced in the exercise plus supplement group than in the other groups (p<0.05). Additionally, the results indicated a significant reduction in Tumor Necrosis Factor-alpha (TNF-α) in the intervention groups compared to the control group
(p<0.05).
Conclusion: Taking omega-3 supplements can positively affect increasing BDNF levels and reducing TNF-α levels in men with multiple sclerosis (MS).

کلیدواژه‌ها [English]

  • Aquatic exercise
  • Omega-3
  • TNF-α
  • BDNF
  • Men
  • Multiple sclerosis

مراجع

  1. Ransohoff RM, Hafler DA & Lucchinetti CF. Multiple sclerosis- a quiet revolution. Nature Reviews Neurology. 2015; 11(3): 134.
  2. Nakhzari Khodakheir J, Haghighi AH & Hamedinia MR. The effects of combined exercise training with aerobic dominant and coenzyme Q10 supplementation on Serum BDNF and NGF levels in patients with multiple sclerosis. J Arak Uni Med Sci. 2018; 21(3): 94-103. [in persian]
  3. Ascherio A & Munger KL. Environmental risk factors for multiple sclerosis. Part I: the role of infection. Annals of neurology. 2007; 61(4): 288-99.
  4. Ghadampour E, Radmehr P & Yousefvand L. The effectiveness of acceptance and commitment-based treatment on social competence and life expectancy of patients with multiple sclerosis. Armaghane 2017; 21(11): 1100-14.
  5. Bekinschtien P, Cammarota M & Katche C. BDNF is essential to promote persistence of long – ternmemory storage. Proc Natl Acad Sci USA. 2008; 105(7): 2711-2716.
  6. Saghebjoo M, Dehghani Firouzabadi M, Etesami M & Mahmudzadeh T. Effect of pilates training on serum levels of brain-derived neurotrophic factor, malondialdehyde and total antioxidant capacity in women with multiple sclerosis. Int J Sports Physiol Perform. 2016; 8(30): 143-58.
    [in persian]
  7. Zar A, Hoseini S, Amirhosseini S & Siavashi N. The effects of eight weeks of endurance training on BDNF, insulin and insulin resistance in rats. Armaghane danesh. 2016; 21(3): 238-248
  8. Salimi Avansar M. The effects of eight weeks interval training and curcumin consumption on TNF- α and BDNF levels in men with metabolic Syndrome. J Ardabil Univ Med Sci. 2017; 3(17):
    299- 310. [in persian]
  9. Osali A & Eskandari M. The effect of three months aerobic exercise with moderate intensity on serum BDNF and TNF-α in women with metabolic syndrome. J mashhad Univ Med Sci. 2016; 59(4): 242-251. [in persian]
  10. Meek TH, Wisse BE, Thaler JP, Guyenet SJ, Matsen ME, Fischer JD & et al. BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production. J Diabetes. 2013; 62(5): 1512-8.
  11. Dalgas U, Stenager E, Jakobsen J, Petersen T, Hansen HJ, Knudsen C & et al. Resistance training improves muscle strength and functional capacity in multiple sclerosis. 2009; 73(18): 1478-84. https://doi.org/10.1212/WNL.0b013e3181bf98b4
  12. Allahbakhshian M, Jafarpouralavi M, Parvizi S & Haghani H. Spiritual connection and quality of life in patients with MS. J Med Res Zahedan. 2010; 12(3): 29-33. [in persian]
  13. Soltani M, Hejazi SM, Nouriyan A, Zendel A & Ashkani M. Effects of aerobic training on improving the water balance in selected patients with multiple sclerosis. J Nurs Midwifery Mashhad. 2009; 2(2): 107-13. [in persian]
  14. Ghaffari S, Ahmadi F, Nabavi SM, Memarian R & Kazemnejad A. The effect of progressive musclerelaxation technique daily living activities in patients with multiple sclerosis. J Rehabilitation. 2008; 2(30): 73-80. [in persian]
  15. Sorori F, Ebrahimi Atri A, Saeedi M & Khorshid Sokhangoy The effect of aquatic training on fatigue in patients with multiple sclerosis. Journal of Mazandaran Medical university. 2012; 22 (94): 54-61. [in persian]
  16. Kargarfard M, Etemadifar M, Esfarjani F, Mehrabi M & Kordavani L. Changes in quality of life and fatigue in women with multiple sclerosis patients after 8 weeks of aquatic training. J Mental Health. 2010; 12(3): 562-73. [in persian]
  17. Taccone-Gallucci M, Manca-di-Villahermosa S, Battistini L, Stuffler RG, Tedesco M & Maccarrone M. N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity. Kidney Int. 2006; 69: 1450-1454.
  18. Tsai CY, Chan JYH, Hsu KS, Chang AYW & Chan SHH. Brain- Derived Neurotrophic Factor Ameliorates Brain Stem Cardiovascular Dysregulation during Experimental Temporal Lobe Status Epilepticus. PLoS ONE. 2012; 7(3): e33527. https://doi.org/10.1371/journal.pone.0033527
  19. Zhu W, Acosta C, MacNeil BJ, Klonisch T, Cortes C, Doupe M & et al. Spinal cord brain derived neurotrophic factor (BDNF) responsive cells in an experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS): Implications in myelin repair. Res Immunol. 2014: 1-19. https://doi.org/5171/2014.612406
  20. Linker RA, Lee DH, Demir S, Wiese S, Kruse N, Siglienti I & et al. Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: Therapeutic implications in a model of multiple sclerosis. 2010; 133: 2248-63.
  21. Yazdani M, Hemayattalab R, Sheikh M & Etemadifar M. The effect of a selected aquatic exercise on balance in subject with Multiple Sclerosis (MS). Journal of Research in Rehabilitation Sciences. 2013; 9(2): 143-52. [in persian]
  22. Cattaneo D, Jonsdottir J, Zocchi M & Regola A. Effects of balance exercises on people with Multiple Sclerosis: A pilot study. Clinical Rehabilitation. 2007; 21(9): 771-81.
  23. Bansi J, Bloch W & Gamper U. Training in MS: influence of two different endurance training protocols (aquatic versus overland) on cytokine and neurotrophin concentrations during three week randomized controlled trial. Mult Scler J. 2012; 19(5): 1–9.
  24. Castellano V & White LJ. Serum brain-derived neurotrophic factor response to aerobic exercise in Multiple Sclerosis. Journal of the neurological sciences. 2008; 269(1-2): 85-91.
  25. Briken S, Rosenkranz S & Keminer O. Effects of exercise on Irisin, BDNF and IL- 6 serum levels in patients with progressive multiple sclerosis. J Neuroimmunol. 2016; 29(9): 53–58.
  26. Khademosharie M, Tadibi V, Behpoor N & Hamedinia M. The effect of 12-week resistance and endurance training on the serum levels BDNF, hematological factors and some immune system indices in women with multiple sclerosis. J Adv Educ Philos. 2019; 15(29): 43-55. [in persian]
  27. Hosseini SM, Mohammadi Z & Talebi V. The effect of regular interval training on histochemical symptoms and cytokine and neurotrophic levels of brain tissue of the Lewis rats in experimental model of multiple sclerosis. J Kashan Univ Med Sci. 2018; 22(5): 450-457. [in persian]
  28. Wu A, Ying Z & Gomez-Pinilla F. DHA dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. 2008; 155(3): 751–759. https://doi.org/10.1016/j.neuroscience.2008.05.061
  29. Matsuoka Y, Nishi D, Yonemoto N, Hamazaki K, Hamazaki T & Hashimoto K. Potential Role of Brain-Derived Neurotrophic Factor in Omega –3 Fatty Acid Supplementation to Prevent Posttraumatic Distress after Accidental Injury: An Open- Label Pilot Study. Psychotherapy and Psychosomatics. 2011; 80(5): 310-312.
  30. Balanzá-Martínez V, Fries GR, Colpo GD, Silveira PP, Portella AK, Tabarés- Seisdedos R & Kapczinski F. Therapeutic use of omega-3 fatty acids in bipolar disorder. Expert Review of Neurotherapeutics. 2011; no.11: 1029-1047.
پژوهش های کاربردی در تغذیه ورزشی و علم تمرین
دوره 1، شماره 3
مهر 1403
صفحه 59-70

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سابقه مقاله

  • تاریخ دریافت: 30 مرداد 1403
  • تاریخ بازنگری: 28 مهر 1403
  • تاریخ پذیرش: 21 آذر 1403
  • تاریخ اولین انتشار: 21 آذر 1403
  • تاریخ انتشار: 21 آذر 1403

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