اثر 4 هفته بی‌تمرینی متعاقب 3 ماه تمرین هوازی بر سطوح سرمی TNF-α و مقاومت انسولین در مردان دیابتی نوع2

نوع مقاله : مقاله پژوهشی

نویسندگان

1 کارشناسی ارشد، گروه علوم ورزشی، دانشگاه قم، قم، ایران.

2 دانشیار، دانشکده تربیت بدنی و علوم ورزشی، واحد تهران جنوب، دانشگاه آزاد اسلامی، تهران، ایران.

3 کارشناسی ارشد، گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی، موسسه آموزشی عالی طلوع مهر، قم، ایران

چکیده

مقدمه: هدف این مطالعه بررسی اثر 4 هفته بی‌تمرینی متعاقب 3 ماه تمرین هوازی بر سطوح سرمی TNF-α و مقاومت انسولین در مردان دیابتی نوع 2 بود.
روش: نمونه آماری این پژوهش 24 نفر مرد مبتلا به دیابت نوع دو 30 تا 40 سال با شاخص توده بدنی 30 تا 34 بودند که داوطلبانه انتخاب و به صورت تصادفی در دو گروه کنترل (12 نفر) و گروه تجربی (12 نفر) قرار گرفتند. گروه تجربی به مدت 12 هفته، و هر هفته سه جلسه تمرین هوازی، تمرینات را با شدت 55 درصد حداکثر بیشینه شروع کرده و در پایان هفته هشتم شدت تمرینات به 75 درصد رسید. 48 ساعت قبل و بعد از اجرای پژوهش و پس از 4 هفته بی‌‌تمرینی، شاخص‌‌های آنتروپومتریکی اندازه‌‌گیری شده و همچنین با هدف اندازه‌‌گیری TNF-α، گلوکز و مقاومت انسولین در هر دوگروه درحالت 12 ساعت ناشتا مقدار 4 سی‌‌سی خون گرفته شد. جهت تجزیه و تحلیل داده‌ها از آزمون تی مستقل، و برای بررسی تغییرات بین‌‌گروهی و تحلیل درون‌‌گروهی از آنالیز واریانس تکرار مکرر به همراه آزمون تعقیبی LSD استفاده شد. سطح معنی‌‌داری p<0.05 درصد بوده و تحلیل داده‌ها با استفاده از نرم‌‌افزار SPSS نسخه 22 انجام شد.
یافته‌‌ها: نتایج نشان داد 12هفته تمرین هوازی باعث کاهش معنی‌‌دار سطوح سرمی (013/0=P) TNF-α، گلوکز ناشتا (000/0=P) و مقاومت انسولین (013/0=P) در گروه تجربی شده، و این تغییرات پس از 4 هفته بی‌‌تمرینی همچنان حفظ شد. در شاخص‌‌های آنتروپومتریکی ازجمله وزن بدن (000/0=P)، توده بدن (000/0=P) و درصد چربی بدن (000/0=P) متعاقب 12هفته تمرین هوازی مشاهده شد، این مقادیر پس از 4 هفته بی‌تمرینی‌‌حفظ شد.
نتیجه‌‌گیری: 3 ماه تمرین هوازی باعث بهبود سطوح TNF-α گلوکز ناشتا، و مقاومت انسولین و نیز کاهش معنی‌‌دار شاخص‌‌های آنتروپومتریکی در مردان دیابتی نوع 2 شد. سطوح این متغیرها پس از 4 هفته بی‌‌تمرینی، همچنان به‌‌میزان معنی‌‌داری پایین‌تر از سطوح پایه حفظ گردید.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of 4 weeks of non-exercise followed by 3 months of aerobic exercise on TNF-α serum levels and insulin resistance in men with type 2 diabetes

نویسندگان [English]

  • Mohammad mahdi Gaeeni 1
  • ,Abdolali Banaeifar 2
  • Narges Chamani 3
1 Master's degree, Department of Sports Science, Qom University, Qom, Iran.
2 Associate Professor, Faculty of Physical Education and Sports Sciences, South Tehran Branch, Islamic Azad University, Tehran, Iran
3 Master's degree, Department of Sports Science, Faculty of Literature and Humanities, Institute of Higher Education Non-profit of Tolo Mehr, Qom, Iran
چکیده [English]

Purpose: The aim of this study was to investigate the effect of 4 weeks of non-exercise followed by 3 months of aerobic exercise on serum levels of TNF-α and insulin resistance in men with type 2 diabetes.
Method: The statistical sample of this research consisted of 24 men aged 30 to 40 with type 2 diabetes and a body mass index of 30 to 34. They were voluntarily selected and randomly divided into two groups: a control group (12 individuals) and an experimental group (12 individuals). Over a period of 12 weeks, the experimental group engaged in three sessions of aerobic training per week. The exercises began at 55% of maximum intensity and by the end of the eighth week,
the intensity had increased to 75%. Anthropometric indicators were measured 48 hours before
and after the research implementation, and after 4 weeks of non-exercise. Additionally, TNF-α, glucose, and insulin resistance were measured in both groups after fasting for 12 hours, with 4 cc of blood drawn. Data analysis involved using an independent t-test and repeated analysis of variance with LSD post hoc test to examine inter-group and intra-group changes. The significance level was set at p<0.05%, and data analysis was conducted using SPSS version 22 software.
Findings: The results showed that 12 weeks of aerobic training caused a significant decrease in serum levels of TNF-α (P=0.013), fasting glucose (P=0.000), and insulin resistance (P=0.013)
in the experimental group, and these changes were maintained after 4 weeks of non-training. Anthropometric indices such as body weight (P=0.000), body mass (P=0.000), and body fat percentage (P=0.000) decreased after 12 weeks of aerobic training, and these values were maintained after 4 weeks of non-training.
Conclusion: Three months of aerobic exercise improved TNF-α levels, fasting glucose, and insulin resistance, as well as significantly reduced anthropometric indices in men with type 2 diabetes. The levels of these variables remained significantly lower than the baseline levels after four weeks of not training.
 
 

کلیدواژه‌ها [English]

  • Aerobic Training
  • Non-Training
  • Glucose
  • Insulin
  • Type 2 Diabetes
  • TNF-α Serum Levels
  • Men

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پژوهش های کاربردی در تغذیه ورزشی و علم تمرین
دوره 1، شماره 2
تیر 1403
صفحه 21-38

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