نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشیار ، گروه تربیت بدنی و علوم ورزشی، واحد بیرجند، دانشگاه آزاد اسلامی، بیرجند، ایران
2 دانشجوی کارشناسی ارشد، گروه تربیت بدنی و علوم ورزشی، واحد بیرجند، دانشگاه آزاد اسلامی، بیرجند، ایران
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Objective: Mild cognitive impairment (MCI) is a transitional stage between normal aging and dementia. Aerobic exercise may affect irisin, BDNF, IGF-1, and VEGF through muscle–brain, neurotrophic, and vascular pathways. This study compared the effects of eight weeks of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on serum irisin, BDNF, IGF-1, and VEGF in older adults with MCI.
Methods: Sixty-nine adults aged ≥60 years with MCI were randomly assigned to HIIT, MICT, or control groups. The HIIT and MICT interventions were performed under supervision three times weekly for eight weeks, with exercise intensity prescribed according to heart rate reserve. The control group received no structured exercise. Fasting venous blood samples were obtained at baseline and 48–72 h after the final session. Serum irisin, BDNF, IGF-1, and VEGF were measured by sandwich ELISA. Data were analyzed using mixed-design repeated-measures ANOVA and Bonferroni post hoc tests, with significance set at P < 0.05.
Results: Groups did not differ in baseline characteristics. Significant time × group interactions were found for BDNF, irisin, IGF-1, and VEGF (all P < 0.001). Both HIIT and MICT significantly increased all biomarkers; however, increases were significantly greater in HIIT than in MICT and control. No significant changes occurred in the control group.
Conclusion: Eight weeks of HIIT and MICT increased serum irisin, BDNF, IGF-1, and VEGF in older adults with MCI, with greater responses following HIIT. Exercise prescription should nevertheless be individualized, and circulating biomarker changes alone do not establish cognitive improvement.
کلیدواژه‌ها [English]
)