نوع مقاله : مقاله پژوهشی
نویسندگان
گروه تربیت بدنی و علوم ورزشی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Objective: Hepatic sarcopenia is a type of secondary sarcopenia that occurs as a result of liver diseases and is characterized by a rapid reduction in muscle mass and strength. The aim of present study was to investigate effect of eight weeks of HIIT on total serum bile acid (TSBA) levels, gene expression of TGR5, IGF-1, and Akt in skeletal muscle of rats with non-alcoholic fatty liver disease (NAFLD).
Methods: Twenty-four male Wistar rats were randomly divided into three groups (n=8 per group): 1) healthy control group, 2) high-fat diet group, and 3) high-fat diet + HIIT group. In the high-fat diet groups, NAFLD was induced by 10 weeks of high-fat diet feeding. Rats in the high-fat diet + HIIT group participated in eight weeks of HIIT (running intervals on a treadmill at 75-90% of maximum speed, with active rest intervals of two minutes of running at 20-30% of maximum speed), five sessions per week. Data analysis was performed using ANOVA test at significance level of less than 0.05.
Results: There were significant differences in changes of skeletal muscle gene expression of TGR5 , IGF-1,and Akt as well as TSBA levels and body weight after eight weeks of HIIT. Eight weeks of HIIT in rats with NAFLD was associated with significant increases in skeletal muscle TGR5, IGF-1, and Akt, while decreasing total bile acid levels in the blood. Therefore, HIIT may play a role in improving hepatic sarcopenia by activating the liver-muscle axis
کلیدواژهها [English]
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