The Effects of 12 Weeks of Aquatic Exercise and Omega-3 Supplementation on Serum BDNF and TNF Levels in Men with Multiple Sclerosis

Document Type : Original Article

Author

Master's degree, Department of Physical Education, Payam Noor University, Mahabad, Iran.

10.22091/arsnes.2024.11223.1015

Abstract

Objective: The aim of the present study was to investigate the effects of 12 weeks of aquatic exercise and omega-3 supplementation on serum levels of BDNF and TNF in men with multiple sclerosis.
Method: A total of 40 men aged 35 to 40 with multiple sclerosis (MS) were randomly selected from a pool of individuals referred to a reputable center in Mahabad. All participants had a documented medical history and had been diagnosed with MS by a neurologist. They were undergoing treatment at the time of selection. This study employed a quasi-experimental design featuring both pre-test and post-test assessments. The participants were divided into four groups of 10: exercise with + supplementation, exercise with + a placebo, omega-3 supplementation, and a control group. The intervention groups engaged in exercise training for 12 weeks, participating in three 60-minute sessions each week. The supplement groups consumed 2 grams of omega-3 in the form of three gel capsules, taken three times a day after each meal. Data analysis was conducted using SPSS version 22 statistical software. The Shapiro-Wilk test was employed to assess the normality of the data distribution. After confirming the normality of the data distribution, an analysis of covariance (ANCOVA) was conducted to compare the mean pre-test and post-test scores of the experimental and control groups. Additionally, Tukey's post-hoc test was employed to analyze the differences among the data from the four groups.
Findings: Exercise training combined with omega-3 supplementation resulted in a significant increase in Brain-Derived Neurotrophic Factor (BDNF) in the intervention groups compared to the control group. Notably, this increase was more pronounced in the exercise plus supplement group than in the other groups (p<0.05). Additionally, the results indicated a significant reduction in Tumor Necrosis Factor-alpha (TNF-α) in the intervention groups compared to the control group
(p<0.05).
Conclusion: Taking omega-3 supplements can positively affect increasing BDNF levels and reducing TNF-α levels in men with multiple sclerosis (MS).

Keywords

Main Subjects

References

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Applied Research in Sports Nutrition and Exercise Science
Volume 1, Issue 3
December 2024
Pages 59-70

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History

  • Receive Date: 20 August 2024
  • Revise Date: 19 October 2024
  • Accept Date: 11 December 2024
  • First Publish Date: 11 December 2024
  • Publish Date: 11 December 2024

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